dafuria_ss This depends on a ton of different factors. Start by researching how the server is set up:
Do they block Fabric altogether ("mods = cheats" mindset)? In that case, you might need VanillaSpoof.
Do they rely on translation exploits? If so, maybe don't use VanillaSpoof and be very careful what other mods you install alongside Wurst.
Which server software and anticheat plugins do they have installed? This can tell you a lot of different things about which hacks will/won't work on that server, where you should change settings, and which hacks you should avoid using because they'd likely get detected.
Do they have VPN detection? / Does your VPN work on that server? This one matters less for your Wurst settings and more for cases where you get IP banned and/or are using multiple accounts.
The only "universal" advice I can give here is to figure out what your own risk tolerance is and act accordingly. How bad is it if you get banned? What items/ranks/etc. would you lose? Do you have alt accounts you can use to lower the risk on your main account? Which hacks you need most? Which hacks are your "low-hanging fruit", i.e. hacks that are hard for the server to detect but still useful to you? Which hacks are more risky? etc.
And then you can make decisions based on that, e.g. "Do I BoatFly donuts around the server owner on a Saturday evening?" Probably not, unless 2 minutes of trolling followed by a quick ban is the goal. "Do I BoatFly this villager over to my iron farm at 7 AM on a Wednesday where I'm the only one on the server?" Maybe there the answer is yes. It's not zero risk, but it's low risk and high reward.
Hope this helps!